Lego Marvel Super Heroes 2, Groot, Rocket Raccoon, Star-Lord, Gamora ve Drax, Doctor Strange, Doctor Octopus, Green Goblin, Spider-Gwen, Spider-Man Noir Spider-Man 2099, Captain America, Thor, Hulk, Hawkeye, Iron Man, Ms. Marvel, Ant-Man, Captain Marvel, Kang the Conqueror gibi kahramanları içerir.